We should taking care of our OWN People ONLY and I bet the streets wouldnt look like this. Those elected officials who are laughing and allowing this? Should be Exiled from public office forever because they NOT doing their jobs Nor taking care of their cities/ States. It disgusting!! But the US government is so corrupt Now that it probably will never happen.
I decided to let people know I have Parkinson’s to encourage others to take action. I was Diagnosed 3 and a half years ago, but my life is full. I act, I give talks, I do my podcast, which I love. The evolving use of performance based software such as Ableton Live and Max/MSP has created new and exciting compositional techniques that intertwine theatrical and musical performance. This paper presents some initial work on the development of an opera using such technologies that is being composed by Kallionp and Chamberlain. Furthermore, it presents two composition case studies by Kallionp: She (2017) and puppet opera Croak (2018), as well as their documentation within the world’s first 360 3D VR recordings with full spatial audio in third order Ambisonics and the application of an unmixing paradigm for focusing and isolating individual voices..
These results would suggest that low levels of CXCL12 and recognition of self peptides presented by self MHC on endothelial cells allows efficient migration of Tregs whereas higher levels of CXCL12 may promote tumour metastases and lead to fugetaxis of the Tregs leading to an even worse prognosis.In conclusion recognition of cognate antigen presented by endothelium enhances antigenspecific transmigration of CD8 and Regulatory T cells. This study therefore reports a novel mechanism for T cell subset infiltration into tumours where high avidity CD8 T cells require recognition of cognate tumour antigen presented on tumour endothelium in the context of MHC class I and conversely regulatory T cell infiltration into tumours depends on the repertoire of self peptides presented on tumour endothelium in the context of MHC class II. Alteration of antigen presentation or MHC expression on tumour endothelium therefore represents a mechanism whereby T cell infiltration can be altered to re direct anti tumour immune responses..
Item Type:ArticleItem Status:Live ArchiveAbstractNanopores have been investigated as a simple and label free tool to characterize DNA nucleotides when a ssDNA strand translocates through the constriction of the pore. Here, a wild type hemolysin protein nanopore was used to monitor DNA repair enzyme activity based on base specific interactions of dsDNA with the vestibule constriction “latch”, a previously unrecognized sensing zone in hemolysin specific for dsDNA structure. The presence of a single abasic site within dsDNA that is in proximity to the latch zone (2 nucleotides) results in a large increase in ion channel current, allowing accurate quantitation of the kinetics of base repair reactions involving an abasic site product.